Ringed sideroblast antioxidant signature. Expression levels of 28 transcripts of key antioxidant genes in the BM of MDS-SLD-RS patients, compared with MDS-SLD patients. Transcripts are ranked in decreasing order of expression in normal BM. Results are expressed as RQ compared with MDS-SLD (mean ± SEM). The horizontal black line (y = 1) represents the MDS-SLD profile (n = 10); blue lines represent the data of MDS-SLD-RS patients (thick and thin lines representing mean and SEM, respectively, n = 13). The gray area corresponds to variations less than twice the normal expression. Dashed vertical lines indicate variants with significant difference. The presence of RS was associated with overexpression of 13 transcripts, including GLRX5. Significant difference with the MDS-SLD (RQ values), *P < .05.