Increased clearance of VWF is associated with lower VWF and FVIII levels at 3 hours after desmopressin administration and a higher bleeding score. Data are presented as median with interquartile range. *P < .05. **P < .001. All analyses are adjusted for age, sex, BMI, and comorbidities. Increased clearance of VWF is defined as a VWFpp/VWF:Ag ratio >2.2.