Original and revised palindromes proposed to destabilize FLT3 exon 14 and trigger MMRDR. (A) The 30-bp c.1778-1807 imperfect palindrome originally proposed. (B) The revised c.1770_1812 structure proposed here. The recurrent c.1770_1793dup ITD corresponding to start → hairpin tip is delineated in blue, and the recurrent c.1770_1811dup start → end duplication in red. FLT3-ITDs start before or within this revised structure, and end within or after, with only rare exceptions.