AMPK regulates leukemic gene networks in LICs. (A) Gene set enrichment analysis revealed reduced expression of MLL-AF9 target genes, JQ1 suppressed genes, and Myc target genes in AMPK KO L-GMPs. (B) Expression of Hoxa9, Meis1, and Myc as shown by the fragments per kilobase of transcript per million mapped reads (FPKM). (n = 3). (C) Gene set enrichment analysis, using the motif gene sets identified Myc motif as the most enriched motif in WT L-GMPs gene expression profile. All data represent mean ± standard deviation. *P < .05; **P < .01; ***P < .001 by Student’s t-test.