Frequency of t-AML/t-MDS mutations in stem cell collection samples prior to MM auto-HSCT. (A) Stem and progenitor populations, granulocytes, and T and B cells were FACS sorted and sequenced. (B) The AML samples and myeloma plasma cell samples were sequenced at different times at the respective clinical presentations. The variant allele frequencies (VAFs) of mutations in the different cell populations are shown. Populations with the highest VAFs are shown in red.