Comparative analysis between cHL and other lymphoid malignancies and cancer subtypes. (A) Mirror plots, centric to genetic alterations identified in cHL, generated by directly comparing cHL (n = 23) to PMBL (n = 37).²²  Focal gain of 2p16.1, observed in PMBL,²²  is labeled to indicate the similarity in the focal gain to that observed at 2p15 in cHL. Non-synonymous mutations, black; CN gain, red; CN loss, blue; SVs, green. *Indicates the genetic alteration was also significant in PMBL. (B) Cancer subtypes sorted by median of coding mutations per Mb per sample, with the tumor type labeled below and number of cases within each cohort shown at the top. EBV⁺ and EBV^– cHL are labeled in red. EBV^– tumors have a high mutational burden, similar to that of carcinogen-induced tumors (melanoma and squamous cell lung cancer).