Recurrent SCNAs and chromosomal rearrangements in cHL. (A) SCNAs labeled with their associated cytoband/arm followed in parentheses by frequency of the alteration, total number of genes, and COSMIC-defined genes. SCNAs that include significantly mutated genes (black) and genes of interest (gray) are highlighted. (B) Arm-level and focal alterations of 2p/2p15. Image visibility graph (IVG) plot of copy number from chromosome 2p indicates a frequent arm-level gain with focal amplification of 2p15 region (XPO1). (C) Arm-level and focal loss of 6q/6q23.3. IGV plot of copy number from chromosome 6q indicates frequent arm-level copy loss and focal copy loss of 6q23.3 (TNFAIP3). (D) Summary of SVs in all cHLs. (E) Circos plots of identified SVs in cHL. (F) ETV6 deletions and insertions. Boxes indicate exons: red, first coding exon; white, protein-coding exon; green, open reading frame (ORF) with intervening introns.