American Society of Hematology

Figure 2.

$Mutational signatures in cHL. (A) Mutational signature analysis with clustering based on the NMD after removal of MSI samples. Identified signatures included C>T at CpG (Aging), AID, and an additional contribution of APOBEC signatures (COSMIC2 and COSMIC13). (B) Mutational clustering. Based on the bimodal distribution of NMD, all mutations were designated as either clustered (NMD ≤10 kb) or nonclustered (NMD ≥10 kb). (C) Signature activity (number of mutations assigned to each signature, y-axis) in each group (red, NMD ≤10 kb; blue, NMD ≥10 kb) across the 21 cHLs (2 MSI hypermutator cases were excluded, x-axis). (D) Relative contribution of each mutational process (Aging, APOBEC, and AID) for the 15 significantly mutated genes. Genes are ordered top to bottom by the fraction of the Aging signature. Error bars show the standard error of the mean. Histogram to the right shows the number of mutations within each mutated gene.$

Mutational signatures in cHL. (A) Mutational signature analysis with clustering based on the NMD after removal of MSI samples. Identified signatures included C>T at CpG (Aging), AID, and an additional contribution of APOBEC signatures (COSMIC2 and COSMIC13). (B) Mutational clustering. Based on the bimodal distribution of NMD, all mutations were designated as either clustered (NMD ≤10 kb) or nonclustered (NMD ≥10 kb). (C) Signature activity (number of mutations assigned to each signature, y-axis) in each group (red, NMD ≤10 kb; blue, NMD ≥10 kb) across the 21 cHLs (2 MSI hypermutator cases were excluded, x-axis). (D) Relative contribution of each mutational process (Aging, APOBEC, and AID) for the 15 significantly mutated genes. Genes are ordered top to bottom by the fraction of the Aging signature. Error bars show the standard error of the mean. Histogram to the right shows the number of mutations within each mutated gene.

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