IKZF5 deficiency misregulates transcription in MKs. (A) Barplot of the number of up- and downregulated Reactome/Ensembl coding genes in CD4⁺ T cells, monocytes, neutrophils, and platelets that are differentially expressed between 14 unrelated controls and 3 unrelated cases. (B) Enriched downregulated pathways in platelets with P < 10⁻⁵. The number of downregulated, upregulated, and nondifferentially expressed genes in each pathway are shown in brackets. (D) Heatmap of expression for genes in the “platelet activation, signaling, and aggregation” Reactome pathway. The expression levels have been row-normalized such that the color represents the log FC of expression between samples and the mean log expression weighted by the number of cases and controls. The cases are on the left-most 3 columns and the controls are on the right-most 14 columns. The PP of association is shown to the left of the heatmap and the significantly down- (blue) and upregulated (yellow) genes are shown to the right of the heatmap. The significantly downregulated genes are listed in blue. FC, fold change.