Differential distribution of somatic mutations in AA, MDS (hypoplastic [Hypo] and hyperplastic [hyper]), and PNH. The red bars depict the percentage of patients affected by a given somatic mutation. Proportion of patients with PNH clones (PIGA mutation) is indicated in blue. Adapted from Negoro et al.¹⁸  IST, immunosuppressive therapy; Normo, normocellular; sMDS, secondary myelodysplastic syndrome: sMDS refers to MDS after AA.