Temporal partitioning of total body iron (LIC) into pancreas and heart in a chronically transfused patient who was minimally adherent to chelation. Measurements of the organ iron by MRI iron are plotted (left axis) as fold change relative to normal. Note that the LIC is already 4 times normal at age 13 years. The pancreas iron (nl = 27 Hz) reaches the level associated with glucose intolerance (100 Hz) at 18.8 years of age, well before the cardiac T2* drops below 20 ms at about 21 years. The cardiac iron starts to rise at 18 years. The LVEF by MRI drops at age 23 years (from Coates and Wood,²⁴  with permission).