Transcriptomic signature of ex vivo CD56⁺ILC1-like cells in peripheral blood from HDs. (A) Principal component analysis (PCA) of ex vivo fluorescence-activated cell–sorted ILC and NK subsets from HDs peripheral blood (n = 3). (B) Heat map of z scores of the expression levels of genes encoding ILC/NK transcription factors (n = 3). (C) Heat map of log counts per million (CPM) of the 100 most differentially expressed genes between CD56⁺ ILC1-like cells and ILC1, ILC2, ILCP, CD56^bright NKs or CD56^dim NKs. The GO pathway to which each gene belongs is represented at the left of each heat map: Metabolic process GO0008152 (“Metabolism"); Lymphocyte activation GO0046649 (“Activation”); Leukocyte migration GO0050900 (“Migration”); Immune effector process GO0002252 (“Effector”). Max, maximum; Min, minimum.