The history of approved therapies in AML. Shown here is a chronological illustration of therapies that have been approved by global therapeutic authorities for the management of AML. Highlighted in lavender are the epigenetic therapies. HMA, hypomethylating agent; IDH2, isocitrate dehydrogenase 2; LDAC, low-dose cytarabine; R/R, relapsed/refractory; t-AML, therapy-related AML.