Mean plots. Mean plots of (A) concizumab plasma concentration vs time; (B) free TFPI vs time; (C) peak TG potential vs time; (D) peak TG potential vs concizumab plasma concentration; (E) PF1+2 vs concizumab plasma concentration; and (F) d-dimers vs concizumab plasma concentration by hemophilia type for patients with last dose level of concizumab 0.15 mg/kg (A-C) and for all dose levels (D-F) in the main parts of explorer4 (HAwI/HBwI) and explorer5 (HA without inhibitors). Baseline free TFPI, mean (standard deviation): 96.3 (11.1) ng/mL. Normal range of peakTG (lower; upper): 26; 147 nmol/L. BC, baseline values for concizumab arm; LLN, lower limit of normal; LLOQ, lower limit of quantification; ULN, upper limit of normal.