Roles of eosinophils in atherosclerosis and arterial thrombosis in mice. (A) Expression of the chemoattractant CCL11 by cells within atherosclerotic plaques leads to the recruitment of eosinophils. Binding of eosinophils to the endothelium leads to surface expression of von Willebrand factor (VWF) and binding and activation of platelets that enhance leukocyte migration into the vessel wall. CCL11 also activates eosinophils and increases levels of circulating eosinophil-platelet aggregates. (B) Administration of FeCl₃ to the outside of the carotid artery leads to integrin-dependent binding of eosinophils. P-selectin–dependent platelet binding to eosinophils induces the release of EETs and MBP, which enhance platelet activation. VSMC, vascular smooth muscle cell. Professional illustration by Somersault18:24.