Model for the subsets of B-PLL based on their genetic parameters and linked to clinical outcome of overall survival. Using the presence or absence of MYC activation and del17p− status, 3 subsets of B-PLL can be discerned. Thus, for leukemic cells characterized with the following possibilities: with no MYC activation and no del17P− (ie, low risk), leukemic cells with MYC activation and no del17P− (ie, intermediate risk), and for leukemic cells with both MYC activation and del17P− (ie, high risk) there exists a hierarchy for overall survival.