Images corresponding to illustrative case 1 (missed viral disease). (A) Low-power view (original magnification ×4) of the liver with hematoxylin and eosin stain showing extensive hemorrhagic necrosis (arrows) in a background of micronodular cirrhosis. (B) High-power view (original magnification ×60) of the liver with hematoxylin and eosin stain demonstrating prominent viral cytopathic changes with eosinophilic nuclear inclusions (arrows). (C) High-power view (original magnification ×60) of the liver with VZV immunostain demonstrating strongly positive staining of atypical multinucleated hepatic cells (arrows).