Figure 2.
KRAS mutant MM cell lines show greatest activation of downstream RAF effectors based on phosphoproteomics. (A) Heatmap of KSEA-predicted activity of the immediate downstream substrates of Ras protein (ARAF, BRAF, and RAF1/CRAF) across the 7 profiled myeloma cell lines. (B) Western blot analysis of RAS, MAPK, and PI3K/AKT pathway signatures in MM cell lines.

KRAS mutant MM cell lines show greatest activation of downstream RAF effectors based on phosphoproteomics. (A) Heatmap of KSEA-predicted activity of the immediate downstream substrates of Ras protein (ARAF, BRAF, and RAF1/CRAF) across the 7 profiled myeloma cell lines. (B) Western blot analysis of RAS, MAPK, and PI3K/AKT pathway signatures in MM cell lines.

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