Figure 2.
Mice treated with subcellular PtdSer exhibit worse lethal GVHD. (A-B) Overall survival (A) and GVHD score (B) of allogeneic transplanted BALB/c recipient mice after transplantation with TCD-BM and treatment with B6 Tcon cells (▼), Tcon cells plus PtdSer (40 μg per mouse given IV) (●), or Tcon cells and PtdSer plus anti–TIM-1 mAb (3D10; 400 μg per mouse given IP) (▪). Control mice that received TCD BM only are indicated (☐). For the survival curve and GVHD score, pooled data from 3 independent experiments are shown (n = 16 per group). The log-rank test was used for statistical evaluation of mouse survival (Kaplan-Meier survival curves), with comparison of Tcon cells plus PtdSer with Tcon cells shown (*P ≤ .05; 2-tailed Student t test). Error bars indicate SEM.

Mice treated with subcellular PtdSer exhibit worse lethal GVHD. (A-B) Overall survival (A) and GVHD score (B) of allogeneic transplanted BALB/c recipient mice after transplantation with TCD-BM and treatment with B6 Tcon cells (▼), Tcon cells plus PtdSer (40 μg per mouse given IV) (●), or Tcon cells and PtdSer plus anti–TIM-1 mAb (3D10; 400 μg per mouse given IP) (▪). Control mice that received TCD BM only are indicated (☐). For the survival curve and GVHD score, pooled data from 3 independent experiments are shown (n = 16 per group). The log-rank test was used for statistical evaluation of mouse survival (Kaplan-Meier survival curves), with comparison of Tcon cells plus PtdSer with Tcon cells shown (*P ≤ .05; 2-tailed Student t test). Error bars indicate SEM.

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