Platelet-derived VEGFC promotes lymphangiogenesis after wounding. (A) Schematic of the hemostatic tail lymphatic injury model comparing control (Vegfc^fl/fl) and Vegfc cKO (Vegfc^fl/fl; Rosa-creER^T2) mice. (B) Representative images of tail lymphangiograms across the injury site on day 15 after tail injury in control and Vegfc cKO animals. Yellow arrows indicate restored collecting vessel flow. (C) Healing curves for restoration of lymphatic flow in control (Vegfc^fl/fl) and Vegfc cKO (Vegfc^fl/fl; Rosa-creER^T2) mice. (D) Schematic of the hemostatic tail lymphatic injury model to assess lymphangiogenic repair in Vegfc cKO mice, Vegfc cKO mice with addition of wild-type PRP and Vegfc cKO mice with the addition of Vegfc KO PRP. (E) Representative images of tail lymphangiograms across the injury site on day 15 after tail injury in Vegfc cKO mice, Vegfc cKO mice with addition of WT PRP and Vegfc cKO mice with addition of Vegfc KO PRP. Yellow arrow indicates restored collecting vessel flow. (F) Healing curves for Vegfc cKO mouse tail lymphatic collecting vessels in Vegfc cKO mice, and Vegfc cKO mice with addition of WT or Vegfc cKO PRP to the injury site. Scale bars = 500 µm. *P < .017 (using the Bonferroni method to correct for multiple comparisons).