Effect of normalized FVIII or TFPIα on thrombin generation in 5 F5F8D plasmas. (A) Thrombin generation in F5F8D plasma triggered at 1-pM TF and 5-pM TF (inset). (B) Thrombin generation in 5 F5F8D plasmas with the addition of rFVIII to bring FVIII level to 100 IU/dL or plasmas received 0.5 hours after DDAVP infusion (inset). (C) Thrombin generation in 5 F5F8D plasmas added to with final concentration of 10 ng/mL TFPIα.