Figure 1.
In vivo mouse model of thrombus stability in WT, F5L/+,and F5L/Lmice. The change in thrombus size from baseline (A), number of total (B) and large (C) embolic events, and percentage of thrombus that embolized (D). (E) Representative emboli images found in the pulmonary arteries of WT and F5L/L mice. Number of pulmonary emboli per lung slice (F) and the correlation between large embolic events and PE burden (G). All values are expressed as mean ± SEM; n = 6, 7, and 9 for WT, F5L/+, and F5L/L mice, respectively. *P < .05; **P < .01; ***P < .001, using a 1-way analysis of variance for panels A-D, Student t test for panel F, and linear regression for panel G.

In vivo mouse model of thrombus stability in WT, F5L/+,and F5L/Lmice. The change in thrombus size from baseline (A), number of total (B) and large (C) embolic events, and percentage of thrombus that embolized (D). (E) Representative emboli images found in the pulmonary arteries of WT and F5L/L mice. Number of pulmonary emboli per lung slice (F) and the correlation between large embolic events and PE burden (G). All values are expressed as mean ± SEM; n = 6, 7, and 9 for WT, F5L/+, and F5L/L mice, respectively. *P < .05; **P < .01; ***P < .001, using a 1-way analysis of variance for panels A-D, Student t test for panel F, and linear regression for panel G.

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