PN-1 inhibition enhances thrombin generation in PRP from patients with severe hemophilia A and patients with severe hemophilia B after collagen-induced platelet activation. Representative thrombin generation profiles from a patient with severe hemophilia A (A) and a patient with severe hemophilia B (C) after TF and collagen activation. Peaks were measured in PRP from patients with severe hemophilia A (B) and patients with severe hemophilia B (D), incubated with 100 µg/mL irrelevant IgG antibody or 100 µg/mL anti-PN-1 antibody. Each dot represents 1 patient. Values are means ± SEM. A non-parametric1-way ANOVA test followed by a multiple comparison test was used; *P < .05.