PN-1 inhibition has no effect on thrombin generation in PRP from patients with severe hemophilia A and patients with severe hemophilia B. Representative thrombin generation profiles from a patient with severe hemophilia A (A) and a patient with severe hemophilia B (C). Peaks were measured in PRP from patients with severe hemophilia A (B) and patients with severe hemophilia B (D), incubated with 100 µg/mL irrelevant IgG antibody or 100 µg/mL anti-PN-1 antibody. Each dot represents 1 patient. Values are means ± SEM. A nonparametric 1-way ANOVA test followed by a multiple comparison test was used.