PN-1 inhibition enhances thrombin generation in PRP from mild and moderate patients with hemophilia A and B. Peaks were measured in PRP from patients with mild and moderate hemophilia A (A-B) or patients with hemophilia B (C-D), incubated with 100 µg/mL irrelevant IgG antibody or 100 µg/mL anti-PN-1 antibody. Each dot represents 1 patient. Values are means ± SEM. A nonparametric 1-way analysis of variance (ANOVA) test followed by a multiple comparison test was used. *P < .05; **P < .01.