Dynamics of neoplastic clonotypes in the skin and blood. Three patients were followed longitudinally with multiple skin biopsies and/or blood sampling. All shared neoplastic clonotypes are plotted on the time axis for individual patients: MF4 (A), MF11 (B), and MF34 (C). The location and type of lesion are indicated for each patient on a silhouette (green circle, plaque; red square, tumor). Each dotted line corresponds to a single, shared clonotype of the indicated amino acid sequence of CDR3β. Circles above the line are skin clonotypes (open red, tumor; open green, plaque), whereas the solid red circles below the line are the clonotypes detected in the blood. The size of the dot is proportional to the frequency of the shared clonotype in the sample.