Genomic profile of somatic mutations and copy number variants (CNVs) in baseline samples, as detected by NGS data. Each column represents a patient (n = 110) and each row represents a gene that is mutated in at least 2 patients (n = 22). In the bottom of the figure, each row represents a CNV event (n = 10). The bar plot (top) indicates the number of somatic mutation(s) per patient, colored according to the type of the alteration. The bar plot on the right shows the number of somatic mutations per gene (top) or CNV event (bottom). The frequency of mutations in the cohort is listed on the left border of the figure. The clinical response to treatment is displayed in the annotation bar at the lower axis of the figure according to the legend. The second annotation bar at the bottom panel denotes the classification of each patient according to the molecular classification criteria.³⁴