Effect of THPO-ASO–treatment on platelet count and TPO levels in a baboon. (A) Platelet counts and TPO levels during weekly repeat administration of unconjugated THPO-ASO (days 0 to 28) and during the recovery/follow-up period (until day 177) in a juvenile male baboon. (B) Platelet counts and TPO levels during weekly repeat administration of GaINac-conjugated THPO-ASO (days 0 to 28) and during the follow-up period (until day 55) in the same baboon.