RS-AML transcription program. (A) PCA and t-SNE plots using RNA-seq results of the indicated cell types. Previously published RNA-seq was included for the following cell types: NBM (GSE63569), non-RS-AML (Blueprint study), SF3B1^mut MDS (GSE63569) and SF3B1^mut AML (combination of TCGA data set, Blueprint study and own data). (B) Biological process enrichment for genes upregulated (1464) in RS-AML as compared with non-RS-AML. (C) MEP signature comparison among RS-AML, non-RS-AML, and NBM.