Table 4.

Recommendations for second-line systemic treatments in cGVHD and levels of evidence per the Regensburg Consensus Conference90 

Recommendations for second-line systemic treatments in cGVHD and levels of evidence per the Regensburg Consensus Conference90

TAM indicates transplantation-associated microangiopathy; CNI, calcineurin inhibitor; HCQ, hydroxychloroquine; and TAI, total abdominal irradiation.

*Recommendations were indicated as follows: A, should always be offered; B, should generally be offered; C, optional; C-1, use in second-line therapy justified; C-2, use in greater than second-line therapy justified; C-3, use limited to specific circumstances because of increased risk profile; C-4, experimental; and D, should generally not be offered.

†Evidence was indicated as follows: I, evidence from > 1 randomized controlled trials; II, evidence from 1 well-designed clinical trial without randomization, from cohort analytic studies, or from dramatic results of uncontrolled experiments; III, evidence from opinions of respected authorities; III-1, several reports from retrospective evaluations or small uncontrolled clinical trials; III-2, only 1 report from small uncontrolled clinical trial or retrospective evaluations; and III-3, case reports.

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