Plasma levels and platelet aggregation. Top panel shows the plasma levels of VWF:Ag, VWF:RCo, and VWF:CB in controls (white circles); in patients with BUC (grey circles); and in patients with VWD (black circles). Horizontal lines correspond to the 2.5 percentile of the 299 controls: 42, 37, and 39 IU/dL for VWF:Ag, VWF:RiC, and VWF:CBA, respectively. Reproduced with permission from Quiroga et al.⁴  Bottom panel shows scatter plots of maximal percentage of platelet aggregation in controls (white circles), patients with BUC (grey circles), and patients with PFDs (black circles). The scatter plot presents the individual values of maximal percentage aggregation with each agonist. Horizontal lines correspond to the 2.5 percentile of 299 controls. AA indicates 1mM arachidonic acid; EPI, 10μM epinephrine; and COLL, collagen. Reproduced with permission from Quiroga et al.⁴⁵