Changes of the frequency of major complications of PEX, days of PEX treatment, and frequency of treatment with corticosteroids and rituximab in patients with their initial episode of TTP associated with severe ADAMTS13 deficiency, 1996-2011
PEX complications have been documented as described previously16 in all Registry patients from June 25, 1996 through June 24, 2011. Results have been analyzed every 3 years. The data describe the results of the 5 consecutive 3-year periods for 66 patients with ADAMTS13 activity < 10%. Of the 70 patients described in Table 3, 1 patient died before a central venous catheter was placed for PEX, 2 patients presented before June 25, 1996, and 1 patient presented after June 24, 2011. A 1-sided Cochran-Armitage Trend test was performed to determine whether the proportion of patients with major complications, days of PEX, or treatment with steroids or rituximab changed across the 5 time periods. Adapted with permission from Som et al.5
