NSC697923 appears to inhibit NF-κB activation by multiple stimuli. SUDHL-6, RAW264.7, and MEF cells were treated with NSC697923 or DMSO (control) for 30 minutes before stimulated with the PMA (100 ng/mL), RANKL (15 ng/mL), and LPS (1.5 μg/mL) for the indicated times. The levels of IκBα phosphorylation and total IκBα in the indicated samples were assessed by Western blotting.