Figure 3
Figure 3. Regulated protein networks in FLA2 versus FLB1 leukemias. Protein abundance and phosphorylation data were analyzed with the STRING database (http://string.embl.de) resulting in a network composed of 2779 nodes and 29 386 edges. A GO analysis was performed for extracting significant (P < .05) subsets of proteins differentially regulated in FLA2 and FLB1 leukemias. Shown are the 4 most significant subnetworks affected: chromatin and histone modifiers, protein kinases, RNA processing, and nuclear import/export. Proteins/nodes are grouped according to their function and/or family. Color code indicates differentially expressed and/or phosphorylated proteins in FLA2 and FLB1 leukemias as described in the caption.

Regulated protein networks in FLA2 versus FLB1 leukemias. Protein abundance and phosphorylation data were analyzed with the STRING database (http://string.embl.de) resulting in a network composed of 2779 nodes and 29 386 edges. A GO analysis was performed for extracting significant (P < .05) subsets of proteins differentially regulated in FLA2 and FLB1 leukemias. Shown are the 4 most significant subnetworks affected: chromatin and histone modifiers, protein kinases, RNA processing, and nuclear import/export. Proteins/nodes are grouped according to their function and/or family. Color code indicates differentially expressed and/or phosphorylated proteins in FLA2 and FLB1 leukemias as described in the caption.

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