NFAT signaling in DCs in response to microbes, TLR ligands, and particulates. Schematic representation of a DC activated by different stimuli. Microbial stimuli, both bacterial and fungal, activate Ca²⁺ flux, which promotes NFAT dephosphorylation through close collaboration with TLR signaling. Stimulation also occurs in response to particulate β-glucan, being recognized by the dectin 1 clusters that are required for Syk pathway activation and NFAT nuclear translocation.