Calcineurin/NFAT-dependent IL-2 release in DCs. DCs produce IL-2 early after encountering bacterial or fungal cell wall components. Ligand binding to dectin 1 signals through ITAM-like motifs, leading to the recruitment of Syk family kinases and Ca²⁺ influx, which culminates in NFAT translocation to the nucleus, gene transcription, and extracellular release of IL-2 cytokine. Alternatively, ligand binding to CD14 requires collaboration of MD2 and Src-family kinases (SFKs) with TLR4 molecule to initiate this pathway.