Functional analysis of the top-scoring network of AE9a dysregulated genes. AE9a dysregulated genes with at least a 2-fold change (823 genes) were analyzed using Ingenuity Pathway Analysis. A top-scoring network is shown here. The network consists of 35 genes, whose functions involve the regulation of hematopoiesis, cell-cycle, cancer, and cell death. These genes are represented as nodes with their shape indicating the functional class of the gene product (shown at bottom right). The biologic relationship between 2 nodes is represented as a line, solid being direct and dashed being indirect relationship (see legends at bottom left). The intensity of the node color indicates the degree of up (red) or down (green) regulation. Genes marked with circles are also target genes of ChIP-chip assays. Blue: HA only targets. Red: AML1 only targets. Purple: HA and AML1 common targets.