Growth arrest but not increased cell death is evident in lymphoma cells and premalignant B-lymphoid cells from Eμ-myc/E6AP^+/− mice. (A) Spontaneous death of Eμ-myc/E6AP^+/− and control (E6AP^+/+) Eμ-myc lymphoma cells was assayed by staining with PI followed by FACS analysis (n = 10/genotype). Values represent means ± SD. (B) Spontaneous death of BM derived premalignant B-lymphoid cells from 4-week-old Eμ-myc/E6AP^+/− and control (E6AP^+/+) Eμ-myc mice was assayed by staining with PI followed by FACS analysis (n = 3/genotype). Values represent mean ± SD. (C) Cell-cycle analysis of Eμ-myc/E6AP^+/− and control (E6AP^+/+) Eμ-myc lymphoma cells showing percentages of cells in each of the phases of cell cycle (n = 10/genotype; *P < .001, **P < .01). Values represent mean ± SD. (D) Cell-cycle analysis of BM derived premalignant B-lymphoid cells of 4-week-old Eμ-myc/E6AP^+/− and control (E6AP^+/+) Eμ-myc mice was performed by staining with PI, showing percentages of cells in each of the phases of cell cycle (n = 3/genotype; *P < .001; **P < .01). Values represent mean ± SD.