UM CLL cells have a significantly greater activity of the Mev pathway compared with M CLL cells. Mev pathway metabolites were measured in CLL cells cultures from M and UM patients. (A) Cholesterol production. UM CLL cells (n = 20) produced significantly greater levels of cholesterol compared with M CLL cells (n = 33; *P = .034). (B) FPP production. UM CLL cells (n = 20) produced significantly greater levels of FPP compared with M CLL cells (n = 33; *P = .026). (C) IPP_in production. IPP_in was significantly greater in UM (n = 17) than in M (n = 28) CLL cells (*P = .019). (D) IPP_ex production. IPP_ex was significantly greater in UM (n = 19) than in M (n = 27) CLL cells (*P < .001). Bars represent mean values ± SEM.