Gene expression profiling of CLL cells' metabolic activity. The expression level of enzymes involved in the main cellular metabolic pathways was retrospectively analyzed in M (n = 13) and UM (n = 4) CLL cells. Between-groups comparison of Z-scores indicates that the Mev pathway was significantly greater in UM CLL cells than in M cells (median Z-score 4.2 and 3.6, respectively, *P < .01; A). No significant differences were found in the analysis of the pyruvate pathway (B), glycolysis (C), and Krebs cycle (D). Box and whiskers plot represent median values, first and third quartiles, and minimum and maximum values for each dataset.