Figure 2
Figure 2. Evidence of circulating NET biomarkers in the mouse model of TRALI. Quantification of (A) DNA, (B) nucleosomes, and (C) MPO concentrations in plasma from a group of mice challenged intraperitoneally with LPS (0.1 mg/kg) and intravenously with an isotype control antibody (1 mg/kg; LPS + Ctrl Ab); n = 7, 7, and 4 for panels A, B, and C, respectively), and from a TRALI group that received both LPS and the anti–H-2Kd antibody (1 mg/kg; LPS + H-2Kd Ab; n = 7, 7, and 4 for panels A, B, and C, respectively). Blood was taken 2 hours after antibody injection. *P < .05.

Evidence of circulating NET biomarkers in the mouse model of TRALI. Quantification of (A) DNA, (B) nucleosomes, and (C) MPO concentrations in plasma from a group of mice challenged intraperitoneally with LPS (0.1 mg/kg) and intravenously with an isotype control antibody (1 mg/kg; LPS + Ctrl Ab); n = 7, 7, and 4 for panels A, B, and C, respectively), and from a TRALI group that received both LPS and the anti–H-2Kd antibody (1 mg/kg; LPS + H-2Kd Ab; n = 7, 7, and 4 for panels A, B, and C, respectively). Blood was taken 2 hours after antibody injection. *P < .05.

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