Correlation of peak cytokine concentrations and body temperature with clinical response to blinatumomab treatment in MRD⁺ ALL patients. Sixteen patients responding with a complete molecular response in BM after the first treatment cycle are compared with 4 nonresponders. All depicted values represent individual (A-E) peak cytokine concentrations or (F) peak body temperatures within the first 3 days after infusion start. Statistical analyses are shown for (A) IL-2, (B) IL-6, (C) IL-10, (D) IFN-γ, (E) TNF-α, and (F) body temperature. IL-4 concentrations were below the limit of detection throughout all patients and were not analyzed. Bars give median values; brackets indicate P values.