IRF-8 regulates distinct transcriptional programs in myeloid and lymphoid progenitors. ALPs or common myeloid progenitors (CMPs) were double-sorted from Irf8^+/+ or Irf8^−/− mice and gene expression profiling was carried out by microarray analysis. Venn diagram shows genes that are specifically modulated in the common myeloid progenitor or ALP pathways, as well as genes that are coordinately dysregulated in both pathways. The genes listed in the tables show known transcription factors. Numbers represent fold changes in Irf8^−/− compared with Irf8^+/+ cells.