Effect of plg treatment on IL-6 expression and STAT3 activation in db/db mice. (A) Comparison of plg levels in the unwounded and wounded areas in db/db mice (n = 8), db/db mice treated with plg (n = 4), and db/+ mice (n = 4). (B) Comparison of the IL-6 levels of db/db mice (n = 8), db/db mice treated with plg (n = 8), and db/+ mice (n = 10). (C) Western blot analysis of the pSTAT3 levels in the skin lysates from unwounded db/db mice, wounded db/db mice, and wounded db/db mice treated with plg (n = 4). β-actin served as a loading control. The level of pSTAT3 was quantified using ImageJ Version 1.41o software. Values are expressed as the intensity of pSTAT3 divided by the intensity of total STAT3. ns indicates not significant. *P < .05; **P < .01.