Supervised gene expression profiling of MLL-rearranged AMLs uncovers 2 different subgroups. Pearson correlation clustering of 35 MLL-rearranged leukemias defined 2 subgroups, an EVI1^pos group and an EVI1^neg group (supplemental Figure 1). Supervised analysis revealed 22 probe sets that were differentially expressed between the 2 MLL-rearranged subgroups. Red color corresponds to high correlation, whereas blue color corresponds to low correlation of mRNA expression of genes in patient samples. Note that arrows (←) point to probe sets for EVI1 mRNA expression, which are part of the distinctive signature separating the 2 clusters.