Figure 7
Inhibitory effect of β15-42–containing dimeric fibrin fragments on neutrophil infiltration in vivo in a mouse model of peritonitis. The recombinant (β15-66)2 fragment (A) or the synthetic (β15-44)2 fragment (B), each in 200 μL of PBS at 80μM (total dose per mouse was 16 nmol), was injected intravenously in wild-type and VLDLR−/− mice; control mice were injected with 200 μL of PBS (A) or scrambled (β15-44)2 fragment (Scr. fr.) at 80μM in 200 μL of PBS (B). The number of infiltrated leukocytes (neutrophils) was estimated as described in the “Leukocyte transendothelial migration assay.” The results are means ± SEs (n = 4, A; n = 6, B). **P < .01.
