Figure 2
Mutant alleles of Rhbdf2 are noncomplementary and cause a specific block in TNFα secretion. Thioglycollate-elicited peritoneal cells were isolated from mice of the indicated genotypes, and cultured in the presence of 200 pg/mL MALP-2, 1 ng/mL LPS, or media alone (-) for 4 hours. TNFα (A) and IL-6 (B) was then measured in the culture supernatant.

Mutant alleles of Rhbdf2 are noncomplementary and cause a specific block in TNFα secretion. Thioglycollate-elicited peritoneal cells were isolated from mice of the indicated genotypes, and cultured in the presence of 200 pg/mL MALP-2, 1 ng/mL LPS, or media alone (-) for 4 hours. TNFα (A) and IL-6 (B) was then measured in the culture supernatant.

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