Solulin improves fibrin viscoelasticity. At low concentrations (1.4-35.7nM), Solulin increases the MCF and CLT in human hemophilic blood. Increases in MCF and CLT are accompanied by an increase in the AUEC, which is used as a measure of clot stability or resistance to fibrinolysis. At high concentrations of Solulin (71.4nM), the MCF, CLT, and AUEC are reduced compared with the no-Solulin control. These data are representative of those obtained when Solulin and hemophilic blood (< 1% fVIII:C) are titrated.