Cellular programs deregulated in HSTL. Asterisks show resting γδ T cells. Representative molecular pathways, among those differentially expressed (as shown by enrichment analysis, see Table 6 and supplemental Table 5) in HSTL by comparison with NKTCL, PTCL-NOS, and normal γδ T cells, are illustrated. (A) NK-cell–mediated cytotoxicity. (B) TCR signaling pathway. (C) Sprouty regulation of the tyrosine kinase signal pathway. (D) Sonic hedgehog pathway. (E) Multidrug resistance factors. (F) Cell cycle. For each line, green corresponds to the minimal intensity value (min), red corresponds to the maximal intensity value (max), and black corresponds to (max − min)/2.