HSTL samples cluster separately to the other T-cell lymphomas irrespective of their αβ or γδ lineage. Unsupervised consensus clustering of GEPs of 9 HSTL, the HSTL cell line, 7 NKTCL, 16 PTCL-NOS, and 17 AITL tumor samples. Core clusters (C1, C2, C3, and C4) are defined as groups of at least 5 samples being co-clustered in at least 8 of the 16 initial partitions (see supplemental Methods). Fisher exact test P values for the association between the core clusters C1/C2/C3/C4 and the sample's annotations (lymphoma type, material type, and TCR type) are shown in red. Lymphoma types: H indicates HSTL; N, NKTCL; A, AITL; and P, PCTL-NOS. Material types: C indicates cell line; S, sorted tumor cells; and T, tissue sample. TCR types: A indicates α-β; G, γ-δ.